: any of a breed of very large massive powerful smooth-coated dogs that are apricot, fawn, or brindle and are often used as guard dogs
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Meanwhile, in 2004, a Neapolitan mastiff broke the Guinness World Record for most puppies after giving birth to 24.—Gabrielle Rockson, PEOPLE, 1 May 2026 Cane Corsos are part of the mastiff family.—David Goodhue, Miami Herald, 17 Feb. 2026 But just reaching the elite, champions-only show is a major accomplishment in dogdom, especially for first-timers such as Joseph Carrero and his Neapolitan mastiff, Dezi.—CBS News, 4 Feb. 2026 But just reaching the elite, champions-only show is a major accomplishment in dogdom, especially for first-timers such as Joseph Carrero and his Neapolitan mastiff, Dezi.—Jennifer Peltz, Chicago Tribune, 3 Feb. 2026 See All Example Sentences for mastiff
Word History
Etymology
Middle English mastif, from Medieval Latin mastivus, from Vulgar Latin *masuetivus, from Latin mansuetus tame — more at mansuetude